Journal article
Highly porous and mechanically robust polyester poly(ethylene glycol) sponges as implantable scaffolds
B Ozcelik, A Blencowe, J Palmer, K Ladewig, GW Stevens, KM Abberton, WA Morrison, GG Qiao
Acta Biomaterialia | Published : 2014
Abstract
The development of suitable scaffolds plays a significant role in tissue engineering research. Although scaffolds with promising features have been produced via a variety of innovative methods, there are no fully synthetic tissue engineering scaffolds that possess all the desired properties in one three-dimensional construct. Herein, we report the development of novel polyester poly(ethylene glycol) (PEG) sponges that display many of the desirable scaffold characteristics. Our novel synthetic approach utilizes acid chloride/alcohol chemistry, whereby the reaction between a hydroxyl end-functionalized 4-arm PEG and sebacoyl chloride resulted in cross-linking and simultaneous hydrogen chloride..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
The authors thank A/Prof. Andrea O'Connor (Department of Chemical and Biomolecular Engineering, The University of Melbourne) for the use of facilities, Dr. Phong Tran (Department of Chemical and Biomolecular Engineering, The University of Melbourne) for assistance with in vitro cell viability assays, Mr. Roger Curtain (Advanced Microscopy Facility, Bio21) for assistance with scanning electron microscopy, and O'Brien Institute for providing facilities for in vivo studies and histological analysis. The authors acknowledge The University of Melbourne and the Australian Research Council (ARC) for scholarship and fellowship support (BO: Melbourne Research Scholarship; GGQ: ARC Future Fellowship FT (FT110100411); KL: ARC Super Science Fellowship (FS 110200025)).